Title :
Synthesis of an nimble Pharmaceutical Ingredient, Aspirin ( Including Raw Materials and Product Purity Checks )
figure:
Class:
Lab partners:
Aim: The aim of this experiment is to fig up and recrystallise Aspirin, determine the percentage yield by mass of intersection, preform a test to check for phenols, and characterise it by its run point. The following is the reactions scheme:
Method: -[Lab Manual Pages 3, 4 & 5]-
Results and Calculations:
complexSalicylic AcidAcetic AnhydrideAspirin
AppearanceWhite PowderClear, pallid liquidWhite Crystals
Molar Mass (g/ mole)138g/mol102g/mol180g/mol
Density if liquid (g/cm3)1.08g/cm3
Weight use (g)2.868g5.4gN/A
Moles used (mol)0.0207mol0.0529molN/A
Limiting Reagent ??N/A
Theoretical regress of Products in molesN/AN/A0.0207M
Theoretical Yield of Product in Grams N/AN/A3.726g
Calculations from table ^ :
Moles of Salicylic Acid : Moles= Mass X Mr => M = 2.868 X 138 = 0.0207moles
Moles of Acetic Anhydride : M = 5.4 X 102 = 0.0529moles
Theoretical Yield in moles : moles of limiting reagent = 0.0207moles
Theoretical Yield in Grams : Moles of limiting reagent X Mr of Product :
= 0.0207mol X 180g/mol = 3.
726g
Melting Points
CompoundSalicylic dot (raw material)Recrystallised Aspirin
Expected MP cherish157-161oC138-140oC
Actual MP Value158-160oC137-139oC
Percentage yield:
Percentage yield = 2.214/3.72 ? 100 = 59.52% => 60%
Test for phenols:
SamplesCrude AspirinRecrystallised AspirinSalicylic Acid
Colour channelise of Samples + 1cmoC methanol
Yellowish
Yellowish
Purple
InferencePhenol non presentPhenol not presentPhenol Present
Post- functional Questions :
Q1 What did your melting point indicate about the purity of your product? Explain your answer.
¬The melting point indicated that the prove obtained was pure. If a sample differs by 1-2 oC it is...If you want to get a full essay, invest it on our website: Orderessay
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